Mouse Hdac7/ Histone deacetylase 7 CLIA Kit
组蛋白脱乙酰酶7

货号:

U11378m

商标:

EIAab^®

监管等级:

RUO

别名:

Histone deacetylase 7A, HD7a, HD7, Hdac7a

检测方法:

CLIA

特异性:

Natural and recombinant mouse Histone deacetylase 7

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Mouse Hdac7 CLIA Kit

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通用注释

亚单元:

Interacts with KDM5B (By similarity). Interacts with KAT5 and EDNRA. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with ZMYND15. Interacts with PML (By similarity). Interacts with FOXP3.

功能:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3.

亚细胞位置:

Nucleus Cytoplasm In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

数据库链接

UniGene:

Mm.384027

SMR:

Q8C2B3

STRING:

10090.ENSMUSP00000112110

KEGG:

mmu:56233

Pfam:

PF00850

Uniprot: