EIAab
首页  >  重组蛋白  >  Human HDAC7 Recombinant Protein
HDAC7 (基因名), Histone deacetylase 7 (蛋白名), hdac7_human.
产品名称:

Human HDAC7/ Histone deacetylase 7 Recombinant Protein
组蛋白脱乙酰酶7

货号:

R11378h

商标:
EIAab®
监管等级:
别名:

Histone deacetylase 7A, HD7a, HD7, HDAC7A

序列号:
Q8WUI4
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human HDAC7 Protein
规格 & 价格: cart
×
Human HDAC7 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12q13.11 by HGNC 12q13.11 by Entrez Gene 12q13.11 by Ensembl
HDAC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15 (By similarity). Interacts with PML (isoform PML-4). Interacts with FOXP3.


功能:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).


亚细胞位置:
Nucleus Cytoplasm In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.


该产品尚未在任何出版物中被引用。

[1].
"Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2."

[2].
"Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo."

[3].
"β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells."

[4].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[5].
"Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin."

[6].
"Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."

[7].
"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling."

[8].
"Novel structural insights into class I and II histone deacetylases."

[9].
"Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity."

[10].
"Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com