Human JAK3/ Tyrosine-protein kinase JAK3 CLIA Kit
酪氨酸蛋白激酶JAK3

货号:

U0425h

商标:

EIAab^®

监管等级:

RUO

别名:

Janus kinase 3, Leukocyte janus kinase, JAK-3, L-JAK

检测方法:

CLIA

特异性:

Natural and recombinant human Tyrosine-protein kinase JAK3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Signal Transduction

规格 & 价格:

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Human JAK3 CLIA Kit

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通用注释

亚单元:

Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.

功能:

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

亚细胞位置:

Endomembrane system Peripheral membrane protein Cytoplasm

数据库链接

UniGene:

Hs.515247

SMR:

P52333

STRING:

9606.ENSP00000391676

KEGG:

hsa:3718

MIM: