Jak3 (基因名), Tyrosine-protein kinase JAK3 (蛋白名), jak3_mouse.
产品名称:
Mouse Jak3/ Tyrosine-protein kinase JAK3 CLIA Kit
酪氨酸蛋白激酶JAK3
货号:
U0425m
商标:
EIAab®
监管等级:
别名:
Janus kinase 3, JAK-3
检测方法:
CLIA
特异性:
Natural and recombinant mouse Tyrosine-protein kinase JAK3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Signal Transduction
通用注释
亚单元:
Interacts with STAM2 and MYO18A. Interacts with SHB.
功能:
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
亚细胞位置:
Endomembrane system
Peripheral membrane protein
Cytoplasm
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