Jpt1 (基因名), Jupiter microtubule associated homolog 1 (蛋白名), jupi1_mouse.
产品名称:
Mouse Jpt1/ Jupiter microtubule associated homolog 1 CLIA Kit
货号:
U15606m
商标:
EIAab®
监管等级:
别名:
Hematological and neurological expressed 1 protein, Hn1
检测方法:
CLIA
特异性:
Natural and recombinant mouse Jupiter microtubule associated homolog 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with the complex composed, at least, of APC, CTNNB1 and GSK3B; the interaction takes place with the inactive form of GSK3B (phosphorylated at 'Ser-9').
功能:
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (By similarity). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (By similarity).
亚细胞位置:
Nucleus
Cytoplasm
数据库链接
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