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MACF1 (基因名), Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (蛋白名), macf1_human.

产品名称:

Human MACF1/ Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 CLIA Kit
微管肌动蛋白交联因子1，亚型1/2/3/5

货号:

U15471h

商标:

EIAab^®

监管等级:

RUO

别名:

620 kDa actin-binding protein(ABP620), Actin cross-linking family protein 7, Macrophin-1, Trabeculin-alpha, ABP620, ABP620, ACF7, KIAA0465, KIAA1251, KIAA0754

检测方法:

CLIA

特异性:

Natural and recombinant human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human MACF1 CLIA Kit

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通用注释

亚单元:

Isoform 2 interacts with MAPRE1, CLASP1, CLASP2, AXIN1 and LRP6 (By similarity). Isoform 2 is found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Isoform 2 interacts with GOLGA4.

功能:

Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.

亚细胞位置:

Isoform 1 Cytoplasm Golgi apparatus Localizes to the tips of microtubules.

数据库链接

UniGene:

Hs.472475

SMR:

Q9UPN3

STRING:

9606.ENSP00000354573

KEGG:

hsa:23499

MIM:

608271

Pfam:

PF00307

Uniprot:

Q9UPN3

相关产品

Mouse Macf1 ELISA Kit

序列长度:

7388

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SAAGGQGNSR | RGLNKPSKIP | TMSKKTTTAS | PRTPGPKR

3D 模型:

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Human MACF1/ Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 CLIA Kit 微管肌动蛋白交联因子1，亚型1/2/3/5

U15471h

620 kDa actin-binding protein(ABP620), Actin cross-linking family protein 7, Macrophin-1, Trabeculin-alpha, ABP620, ABP620, ACF7, KIAA0465, KIAA1251, KIAA0754

Human MACF1/ Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 CLIA Kit
微管肌动蛋白交联因子1，亚型1/2/3/5