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Macf1 (基因名), Microtubule-actin cross-linking factor 1 (蛋白名), macf1_rat.

产品名称:

Rat Macf1/ Microtubule-actin cross-linking factor 1 CLIA Kit
微管肌动蛋白交联因子1，亚型1/2/3/5

货号:

U15471r

商标:

EIAab^®

监管等级:

RUO

别名:

Actin cross-linking family 7, Acf7, Aclp7, Macf

检测方法:

CLIA

特异性:

Natural and recombinant rat Microtubule-actin cross-linking factor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Macf1 CLIA Kit

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通用注释

亚单元:

Interacts with MAPRE1, CLASP1, CLASP2 and GOLGA4 (By similarity). Interacts with AXIN1 and LRP6. Found in a complex composed of MACF1, APC; AXIN1, CTNNB1 and GSK3B.

功能:

F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.

亚细胞位置:

Cytoplasm Cytoskeleton Cytoplasm Membrane Cell membrane Cell projection Ruffle membrane Localizes to the tips of microtubules. APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization. The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity).

数据库链接

UniGene:

Rn.213155

STRING:

10116.ENSRNOP00000041065

Pfam:

PF00307

Uniprot:

D3ZHV2

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Mouse Macf1 CLIA Kit

Human MACF1 Protein

序列长度:

5430

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SRRGLTKPSK | IPTMSKKTTT | ASPRTPCPKR |

3D 模型:

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Rat Macf1/ Microtubule-actin cross-linking factor 1 CLIA Kit 微管肌动蛋白交联因子1，亚型1/2/3/5

U15471r

Actin cross-linking family 7, Acf7, Aclp7, Macf

Rat Macf1/ Microtubule-actin cross-linking factor 1 CLIA Kit
微管肌动蛋白交联因子1，亚型1/2/3/5