Mouse Lcn2/ Neutrophil gelatinase-associated lipocalin CLIA Kit
中性粒细胞明胶酶相关脂质运载蛋白

货号:

U1388m

商标:

EIAab^®

监管等级:

RUO

别名:

Lipocalin-2, Oncogene 24p3, SV-40-induced 24p3 protein, Siderocalin LCN2, p25, 24p3, NGAL

检测方法:

CLIA

特异性:

Natural and recombinant mouse Neutrophil gelatinase-associated lipocalin

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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通用注释

亚单元:

Monomer. Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.

功能:

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis (By similarity).

亚细胞位置:

Secreted Cytoplasmic granule lumen Cytoplasmic vesicle lumen Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (PubMed:16377569). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (By similarity).

数据库链接

UniGene:

Mm.9537

SMR:

P11672

STRING:

10090.ENSMUSP00000053962

KEGG:

mmu:16819

Pfam:

PF00061

Uniprot: