OAS3 (基因名), 2'-5'-oligoadenylate synthase 3 (蛋白名), oas3_human.
产品名称:
Human OAS3/ 2'-5'-oligoadenylate synthase 3 CLIA Kit
2 5 -oligoadenylate合酶3
货号:
U1715h
商标:
EIAab®
监管等级:
别名:
p100 OAS, p100OAS, P/OKcl.4, (2-5')oligo(A) synthase 3
检测方法:
CLIA
特异性:
Natural and recombinant human 2'-5'-oligoadenylate synthase 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Monomer.
功能:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
亚细胞位置:
Cytoplasm
Nucleus
数据库链接
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