AGER (基因名), Advanced glycosylation end product-specific receptor (蛋白名), rage_bovin.
产品名称:
Bovine AGER/ Advanced glycosylation end product-specific receptor CLIA Kit
晚期糖基化终末产物受体
货号:
U1956b
商标:
EIAab®
监管等级:
别名:
Receptor for advanced glycosylation end products, RAGE
检测方法:
CLIA
特异性:
Natural and recombinant bovine Advanced glycosylation end product-specific receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Interacts with S100B, S100A1, S100A12, S100A14 and APP. Constitutive homodimer; disulfide-linked.
功能:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
亚细胞位置:
Membrane
Single-pass type I membrane protein
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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