Human SBDS/ Ribosome maturation protein SBDS CLIA Kit

货号:

U14247h

商标:

EIAab^®

监管等级:

RUO

别名:

Shwachman-Bodian-Diamond syndrome protein, CGI-97

检测方法:

CLIA

特异性:

Natural and recombinant human Ribosome maturation protein SBDS

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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Human SBDS CLIA Kit

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通用注释

亚单元:

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7 (PubMed:17643419). Found in a complex consisting of the 60S ribosomal subunit, SBDS and EFL1 (PubMed:26479198).

功能:

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

亚细胞位置:

Cytoplasm Nucleus Nucleolus Nucleus Nucleoplasm Cytoplasm Cytoskeleton Spindle Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903).

数据库链接

UniGene:

Hs.110445

SMR:

Q9Y3A5

STRING:

9606.ENSP00000246868

KEGG:

hsa:51119

MIM:

260400

Pfam: