Rat Taok1/ Serine/threonine-protein kinase TAO1 CLIA Kit
TAO激酶1

货号:

U2238r

商标:

EIAab^®

监管等级:

RUO

别名:

Thousand and one amino acid protein 1, Tao1

检测方法:

CLIA

特异性:

Natural and recombinant rat Serine/threonine-protein kinase TAO1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Taok1 CLIA Kit

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通用注释

亚单元:

Self-associates. Interacts with MAP2K3. Interacts with MAP3K7 (By similarity). Interacts with SPRED1 and TESK1.

功能:

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Rn.30050

STRING:

10116.ENSRNOP00000021368

KEGG:

rno:286993

Pfam:

PF00069

Uniprot: