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TAOK1 (基因名), Serine/threonine-protein kinase TAO1 (蛋白名), taok1_human.
产品名称:

Human TAOK1/ Serine/threonine-protein kinase TAO1 Recombinant Protein
TAO激酶1

货号:

R2238h

商标:
EIAab®
监管等级:
别名:

Kinase from chicken homolog B, MARK Kinase, Prostate-derived sterile 20-like kinase 2, Thousand and one amino acid protein kinase 1, hKFC-B, MARKK, PSK-2, TAOK1, KIAA1361, MAP3K16, MARKK

序列号:
Q7L7X3
来源:
E.coli
种属:
Human
标签:
His
序列:
1-281aa
预估分子量:
30.91 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human TAOK1 Protein
规格 & 价格: cart
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Human TAOK1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human TAOK1 Protein
Recombinant human TAOK1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 17q11.2 by HGNC 17q11.2 by Entrez Gene 17q11.2 by Ensembl
TAOK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with MAP3K7.


功能:
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Human TAO kinase 1 induces apoptosis in SH-SY5Y cells."

[2].
"A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling."

[3].
"MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1."

[4].
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."

[5].
"New gene functions in megakaryopoiesis and platelet formation."
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