MAPT (基因名), Microtubule-associated protein tau (蛋白名), tau_bovin.
产品名称:
Bovine MAPT/ Microtubule-associated protein tau CLIA Kit
微管结合蛋白T
货号:
U1983b
商标:
EIAab®
监管等级:
别名:
Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, TAU
检测方法:
CLIA
特异性:
Natural and recombinant bovine Microtubule-associated protein tau
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Neurosciences
通用注释
亚单元:
Interacts with SQSTM1 when polyubiquitinated. Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4. Binds to CSNK1D.
功能:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
亚细胞位置:
Cytoplasm
Cytosol
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
Cytoskeleton
Cell projection
Axon
Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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