UBR4 (基因名), E3 ubiquitin-protein ligase UBR4 (蛋白名), ubr4_human.
产品名称:
Human UBR4/ E3 ubiquitin-protein ligase UBR4 CLIA Kit
E3泛素连接酶UBR4
货号:
U0192h
商标:
EIAab®
监管等级:
别名:
600 kDa retinoblastoma protein-associated factor, N-recognin-4, RING-type E3 ubiquitin transferase UBR4, Retinoblastoma-associated factor of 600 kDa, Zinc finger UBR1-type protein 1, RBAF600, KIAA0462, KIAA1307, RBAF600, ZUBR1
检测方法:
CLIA
特异性:
Natural and recombinant human E3 ubiquitin-protein ligase UBR4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.
功能:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
亚细胞位置:
Membrane
Multi-pass membrane protein
Cytoplasm
Cytoplasm
Cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
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