UFL1 (基因名), E3 UFM1-protein ligase 1 (蛋白名), ufl1_human.
产品名称:
Human UFL1/ E3 UFM1-protein ligase 1 CLIA Kit
货号:
U4457h
商标:
EIAab®
监管等级:
别名:
E3 UFM1-protein transferase 1, Multiple alpha-helix protein located at ER, Novel LZAP-binding protein, Regulator of C53/LZAP and DDRGK1, KIAA0776, MAXER, NLBP, RCAD
检测方法:
CLIA
特异性:
Natural and recombinant human E3 UFM1-protein ligase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
-
通用注释
亚单元:
Interacts with DDRGK1 (PubMed:20018847, PubMed:20164180, PubMed:25219498). Interacts with UFC1 (PubMed:20018847). Interacts with RELA (PubMed:20164180). Interacts with TRIP4 (PubMed:25219498). Interacts with CDK5RAP3; the interaction is direct (PubMed:20164180, PubMed:20228063).
功能:
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also play a role in nuclear receptor-mediated transcription through TRIP4 ufmylation (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390).
亚细胞位置:
Endoplasmic reticulum
Cytoplasm
Cytosol
该产品尚未在任何出版物中被引用。
反馈墙
评论数 : 0
所有用户
所有用户
默认排序
默认排序
最近
早期
目前还没有评论。
通知
规格
数量
单价 (¥)
小计 1 (¥)
小计 2:
¥
规格
数量
单价 (¥)