Mouse Ufl1/ E3 UFM1-protein ligase 1 CLIA Kit

货号:

U4457m

商标:

EIAab^®

监管等级:

RUO

别名:

E3 UFM1-protein transferase 1, Multiple alpha-helix protein located at ER, Regulator of C53/LZAP and DDRGK1, Kiaa0776, Maxer, Rcad

检测方法:

CLIA

特异性:

Natural and recombinant mouse E3 UFM1-protein ligase 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Ufl1 CLIA Kit

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通用注释

亚单元:

Interacts with DDRGK1 (By similarity). Interacts with UFC1 (By similarity). Interacts with RELA (By similarity). Interacts with TRIP4 (By similarity). Interacts with CDK5RAP3; the interaction is direct (PubMed:21494687).

功能:

E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also play a role in nuclear receptor-mediated transcription through TRIP4 ufmylation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition.

亚细胞位置:

Endoplasmic reticulum Cytoplasm Cytosol

数据库链接

UniGene:

Mm.226295

SMR:

Q8CCJ3

STRING:

10090.ENSMUSP00000100059

KEGG:

mmu:67490

Pfam: