Bovine VPS4B/ Vacuolar protein sorting-associated protein 4B CLIA Kit

货号:

U16056b

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

特异性:

Natural and recombinant bovine Vacuolar protein sorting-associated protein 4B

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Bovine VPS4B CLIA Kit

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通用注释

亚单元:

Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner. Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST. Interacts with IST1 (By similarity). Interacts with VTA1.

功能:

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses). Involved in cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan.

亚细胞位置:

Prevacuolar compartment membrane Peripheral membrane protein Late endosome membrane Peripheral membrane protein Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body (By similarity).

数据库链接

UniGene:

Bt.62714

SMR:

Q0VD48

STRING:

9913.ENSBTAP00000013862

KEGG:

bta:539357

Pfam:

PF00004

Uniprot: