Mouse Vps4b/ Vacuolar protein sorting-associated protein 4B CLIA Kit

货号:

U16056m

商标:

EIAab^®

监管等级:

RUO

别名:

Suppressor of K(+) transport growth defect 1, Protein SKD1, Skd1

检测方法:

CLIA

特异性:

Natural and recombinant mouse Vacuolar protein sorting-associated protein 4B

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Vps4b CLIA Kit

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通用注释

亚单元:

Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner. In vitro, associates on the inside of a helical tubular structure formed by a CHMP2A-CHMP3 polymer. Interacts with CHMP1A, CHMP1B, CHMP4B and CHMP6. Interacts with CHMP2A (PubMed:15173323). Interacts with VPS4A; the interaction suggests a heteromeric assembly with VPS4A (PubMed:12594041). Interacts with VTA1.

功能:

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan.

亚细胞位置:

Prevacuolar compartment membrane Peripheral membrane protein Late endosome membrane Peripheral membrane protein Membrane-associated in the prevacuolar endosomal compartment.

数据库链接

UniGene:

Mm.18705

SMR:

P46467

STRING:

10090.ENSMUSP00000092230

KEGG:

mmu:20479

Pfam:

PF00004

Uniprot: