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FGF1 (基因名), Fibroblast growth factor 1 (蛋白名), fgf1_chick.
产品名称:

Chicken FGF1/ Fibroblast growth factor 1 ELISA Kit
肝素结合生长因子1

货号:

E0032c

商标:
EIAab®
监管等级:
别名:

Acidic fibroblast growth factor, Endothelial cell growth factor, Heparin-binding growth factor 1, aFGF, ECGF, HBGF-1, FGF-1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
39pg/mL
特异性:
Natural and recombinant chicken Fibroblast growth factor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Chicken FGF1 ELISA Kit
规格 & 价格: cart
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Chicken FGF1 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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通用注释


亚单元:
N/A


功能:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.


亚细胞位置:
Secreted Cytoplasm Cytoplasm Cell cortex Cytoplasm Cytosol Nucleus Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery (By similarity).


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