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Jmjd6 (基因名), Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (蛋白名), jmjd6_rat.
产品名称:

Rat Jmjd6/ Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 ELISA Kit
双功能精氨酸去甲基酶和赖氨酸羟化酶JMJD6

货号:

E1916r

商标:
EIAab®
监管等级:
别名:

Histone arginine demethylase JMJD6, JmjC domain-containing protein 6, Jumonji domain-containing protein 6, Lysyl-hydroxylase JMJD6, Peptide-lysine 5-dioxygenase JMJD6, Phosphatidylserine receptor, Protein PTDSR, Ptdsr

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.78-50ng/mL
灵敏度:
0.4ng/mL
特异性:
Natural and recombinant rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Immunology
Rat Jmjd6 ELISA Kit
规格 & 价格: cart
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Rat Jmjd6 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65. Interacts with BRD4 (By similarity). Interacts with LIAT1.


功能:
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.


亚细胞位置:
Nucleus Nucleoplasm Nucleus Nucleolus Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle (By similarity).


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