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Notch4 (基因名), Neurogenic locus notch homolog protein 4 (蛋白名), notc4_mouse.
产品名称:

Mouse Notch4/ Neurogenic locus notch homolog protein 4 ELISA Kit
神经源性位点缺口同系物蛋白4

货号:

E2421m

商标:
EIAab®
监管等级:
别名:

Notch 4, Int-3, Int3

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.09ng/mL
特异性:
Natural and recombinant mouse Neurogenic locus notch homolog protein 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Development Biology
Mouse Notch4 ELISA Kit
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Mouse Notch4 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.


功能:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system.


亚细胞位置:
Notch 4 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.


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