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PKD2 (基因名), Polycystin-2 (蛋白名), pkd2_bovin.
产品名称:

Bovine PKD2/ Polycystin-2 ELISA Kit
多囊蛋白-2

货号:

E14978b

商标:
EIAab®
监管等级:
别名:

Polycystic kidney disease 2 protein homolog, Transient receptor potential cation channel subfamily P member 2, TRPP2

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant bovine Polycystin-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cardiovascular
Bovine PKD2 ELISA Kit
规格 & 价格: cart
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Bovine PKD2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Forms homooligomers. Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1. Interacts with PKD1L1. Interacts with NEK8. Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C. Interacts (via C-terminus) with TRPV4 (via C-terminus).


功能:
Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning.


亚细胞位置:
Cell projection Cilium membrane Multi-pass membrane protein Endoplasmic reticulum Cilium localization requires GANAB.


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