首页 > 重组蛋白 > Human PKD2 Recombinant Protein

PKD2 (基因名), Polycystin-2 (蛋白名), pkd2_human.

产品名称:

Human PKD2/ Polycystin-2 Recombinant Protein
多囊蛋白-2

货号:

R14978h

商标:

EIAab^®

监管等级:

RUO

别名:

Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, Transient receptor potential cation channel subfamily P member 2, PC2, TRPP2

序列号:

Q13563

来源:

E.coli

种属:

Human

标签:

His

序列:

266-375aa

预估分子量:

12.1 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cardiovascular

规格 & 价格:

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Human PKD2 Protein

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产品说明书

数据表:

MSDS:

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文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human PKD2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 4q22.1 by HGNC 4q22.1 by Entrez Gene 4q22.1 by Ensembl

PKD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Forms homooligomers. Isoform 1 interacts with PKD1 while isoform 3 does not (By similarity). Interacts with PKD1L1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP (PubMed:10913159). Interacts with HAX1 (PubMed:10760273). Interacts with NEK8 (By similarity). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts (via C-terminus) with TRPV4 (via C-terminus) (PubMed:18695040).

功能:

Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning.

亚细胞位置:

Cell projection Cilium membrane Multi-pass membrane protein Endoplasmic reticulum Cell membrane Cell surface and cilium localization requires GANAB.

数据库链接

UniGene:

Hs.181272

SMR:

Q13563

STRING:

9606.ENSP00000237596

KEGG:

hsa:5311

MIM:

173910

Pfam:

PF08016

Uniprot:

Q13563

相关产品

Mouse Pkd2 ELISA Kit

Bovine PKD2 ELISA Kit

Mouse Pkd2 CLIA Kit

Bovine PKD2 CLIA Kit

Mouse Pkd2 Protein

序列长度:

968

序列:

仅供参考，详细请咨询（services@eiaab.com）

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968:

STEGMEGAGG | NGSSNVHV

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease."

(PMID: 14993477)

[2].

"[Genetic analysis (PKD2) of autosomal dominant polycystic kidney disease]."

(PMID: 19936001)

[3].

"Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro."

(PMID: 16551655)

[4].

"A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1."

(PMID: 16192288)

[5].

"Mutations of the PKD2 gene in Taiwanese patients with autosomal dominant polycystic kidney disease."

(PMID: 15717641)

[6].

"Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease."

(PMID: 12707387)

[7].

"The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton."

(PMID: 10760273)

[8].

"Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene."

(PMID: 10770959)

[9].

"Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations."

(PMID: 10835625)

[10].

"Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease."

(PMID: 10411676)

[1].

人多囊蛋白-2(PKD2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人多囊蛋白-2(PKD2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人多囊蛋白-2(PKD2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人多囊蛋白-2(PKD2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人多囊蛋白-2(PKD2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人多囊蛋白-2(PKD2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人多囊蛋白-2(PKD2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人多囊蛋白-2(PKD2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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