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PLA2R1 (基因名), Secretory phospholipase A2 receptor (蛋白名), pla2r_bovin.
产品名称:

Bovine PLA2R1/ Secretory phospholipase A2 receptor ELISA Kit
分泌性磷脂酶A2受体

货号:

E2020b

商标:
EIAab®
监管等级:
别名:

180 kDa secretory phospholipase A2 receptor, M-type receptor, PLA2-R

检测方法:
ELISA
特异性:
Natural and recombinant bovine Secretory phospholipase A2 receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cardiovascular
Bovine PLA2R1 ELISA Kit
规格 & 价格: cart
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Bovine PLA2R1 ELISA Kit
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亚单元:
N/A


功能:
Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.


亚细胞位置:
Soluble secretory phospholipase A2 receptor Secreted


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