首页 > 重组蛋白 > Human PLA2R1 Recombinant Protein

PLA2R1 (基因名), Secretory phospholipase A2 receptor (蛋白名), pla2r_human.

产品名称:

Human PLA2R1/ Secretory phospholipase A2 receptor Recombinant Protein
分泌性磷脂酶A2受体

货号:

R2020h

商标:

EIAab^®

监管等级:

RUO

别名:

180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, M-type receptor, PLA2-R, CLEC13C

序列号:

Q13018

来源:

E.coli

种属:

Human

标签:

His

序列:

188-400aa

预估分子量:

23.43 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cardiovascular

规格 & 价格:

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产品说明书

说明书:

MSDS:

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数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human PLA2R1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 2q23-q24 by HGNC 2q23-q24 by Entrez Gene 2q23-q24 by Ensembl

PLA2R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

N/A

功能:

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

亚细胞位置:

Isoform 2 Secreted

数据库链接

UniGene:

Hs.410477

SMR:

Q13018

STRING:

9606.ENSP00000283243

KEGG:

hsa:22925

MIM:

604939

Pfam:

PF00040

Uniprot:

Q13018

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Bovine PLA2R1 ELISA Kit

Mouse Pla2r1 CLIA Kit

Bovine PLA2R1 CLIA Kit

Mouse Pla2r1 Protein

序列长度:

1463

序列:

仅供参考，详细请咨询（services@eiaab.com）

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ENILISDLEK | SDQ

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization."

(PMID: 7721806)

[2].

"Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals."

(PMID: 7925459)

[3].

"Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy."

(PMID: 21323541)

[4].

"Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan."

(PMID: 20937089)

[5].

"The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors."

(PMID: 19730683)

[6].

"Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor."

(PMID: 15611272)

[7].

"Analysis of PLA2R1 and HLA-DQA1 sequence variants in Japanese patients with idiopathic and secondary membranous nephropathy."

(PMID: 28849274)

[8].

"Clinical and Histological Features of Phospholipase A2 Receptor-Associated and Thrombospondin Type-I Domain-containing 7A-Associated Idiopathic Membranous Nephropathy: A Single Center Retrospective Study from China."

(PMID: 30032157)

[9].

"Membranous Nephropathy and Anti-Podocytes Antibodies: Implications for the Diagnostic Workup and Disease Management."

(PMID: 29511687)

[10].

"Inactivating frameshift mutation of putative tumor suppressor genes PLA2R1 and SRPK1 in gastric and colorectal cancers."

(PMID: 28212809)

[1].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人分泌性磷脂酶A2受体(PLA2R1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人分泌性磷脂酶A2受体(PLA2R1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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