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WWOX (基因名), WW domain-containing oxidoreductase (蛋白名), wwox_human.
产品名称:

Human WWOX/ WW domain-containing oxidoreductase ELISA Kit
含有氧化还原酶的WW结构域

货号:

E2982h

商标:
EIAab®
监管等级:
别名:

Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1, FOR, SDR41C1, WOX1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.156ng/mL
特异性:
Natural and recombinant human WW domain-containing oxidoreductase
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Human WWOX ELISA Kit
规格 & 价格: cart
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Human WWOX ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207.


功能:
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.


亚细胞位置:
Cytoplasm Nucleus Mitochondrion Golgi apparatus Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus.


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