AICDA (基因名), Single-stranded DNA cytosine deaminase (蛋白名), aicda_human.
产品名称:
AICDA Antibody
活化诱导胞嘧啶核苷脱氨酶
货号:
M14184Rb-h
商标:
EIAab®
监管等级:
别名:
Activation-induced cytidine deaminase, Cytidine aminohydrolase, AID, AID
反应性:
human
免疫原:
Recombinant human AICDA protein ( R14184h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Epigenetics
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H. Interacts with RNF126.
功能:
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).
亚细胞位置:
Nucleus
Cytoplasm
Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.
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