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OAS3 (基因名), 2'-5'-oligoadenylate synthase 3 (蛋白名), oas3_human.

产品名称:

OAS3 Antibody
2 5 -oligoadenylate合酶3

货号:

M1715Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

p100 OAS, p100OAS, P/OKcl.4, (2-5')oligo(A) synthase 3

反应性:

human

免疫原:

Recombinant human OAS3 protein ( R1715h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human OAS3 Monoclonal Antibody

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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

Monomer.

功能:

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

亚细胞位置:

Cytoplasm Nucleus

数据库链接

UniGene:

Hs.528634

SMR:

Q9Y6K5

STRING:

9606.ENSP00000228928

KEGG:

hsa:4940

MIM: