TAB2 (基因名), TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (蛋白名), tab2_human.
产品名称:
TAB2 Antibody
磷酸化转化生长因子β活化激酶结合蛋白2
货号:
M2882Rb
商标:
EIAab®
监管等级:
别名:
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TGF-beta-activated kinase 1-binding protein 2, TAB-2, KIAA0733, MAP3K7IP2
反应性:
human,mouse,rat
免疫原:
Recombinant human TAB2 protein ( R2882h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Monoclonal
亚型:
Mouse IgG
应用:
推荐产品:
研究领域:
Cancer
R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释
亚单元:
Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TRIM5.
功能:
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
亚细胞位置:
Membrane
Peripheral membrane protein
Cytoplasm
Cytosol
Following IL1 stimulation, translocation occurs from the membrane to cytosol.
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