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UBE2B (基因名), Ubiquitin-conjugating enzyme E2 B (蛋白名), ube2b_human.

产品名称:

UBE2B Antibody
泛素结合酶E2 B

货号:

M1063Rb

商标:

EIAab^®

监管等级:

RUO

别名:

E2 ubiquitin-conjugating enzyme B, RAD6 homolog B, Ubiquitin carrier protein B, Ubiquitin-conjugating enzyme E2-17 kDa, Ubiquitin-protein ligase B, HR6B, RAD6B

反应性:

human,mouse,rat

免疫原:

Recombinant human UBE2B protein ( R1063h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Monoclonal

亚型:

Mouse IgG

应用:

推荐产品:

Goat Anti-Mouse IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human UBE2B Monoclonal Antibody

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R&D 技术数据

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通用注释

亚单元:

Interacts with RAD18, UBR2 and WAC.

功能:

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

亚细胞位置:

Cell membrane Nucleus In peripheral neurons, expressed both at the plasma membrane and in nuclei.

数据库链接

UniGene:

Hs.612096

SMR:

P63146

STRING:

9606.ENSP00000265339

KEGG:

hsa:7320

MIM: