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ADA (基因名), Adenosine deaminase (蛋白名), ada_human.

产品名称:

ADA Antibody

货号:

P1390Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Adenosine aminohydrolase, ADA1

序列号:

P00813

反应性:

human, mouse

免疫原:

corresponding to a sequence mapping at the 2-363aa of P00813

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human ADA Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

HepG2 whole cell lysate was subjected to SDS-PAGE followed by Western Blot with Adenosine deaminaseantibody at dilution of 1:300

Immunohistochemistry of paraffin-embedded human gastric cancer using antibody at 1:100 dilution.

通用注释

亚单元:

Interacts with DPP4 (via extracellular domain) (PubMed:10951221, PubMed:14691230, PubMed:7907293, PubMed:8101391, PubMed:15016824). Interacts with PLG (via Kringle 4 domain); the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824).

功能:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development.

亚细胞位置:

Cell membrane Peripheral membrane protein Extracellular side Cell junction Cytoplasmic vesicle lumen Cytoplasm Lysosome Colocalized with DPP4 at the cell surface.

数据库链接

UniGene:

Hs.654536

SMR:

P00813

STRING:

9606.ENSP00000361965

KEGG:

hsa:100

MIM:

102700

Pfam: