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AICDA (基因名), Single-stranded DNA cytosine deaminase (蛋白名), aicda_human.

产品名称:

AICDA Antibody

货号:

P14184Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Activation-induced cytidine deaminase, Cytidine aminohydrolase, AID, AID

序列号:

Q9GZX7

反应性:

human

免疫原:

Recombinant human AICDA protein ( R14184h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human AICDA Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Anti-AICDA antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

通用注释

亚单元:

Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H. Interacts with RNF126.

功能:

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

亚细胞位置:

Nucleus Cytoplasm Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.

数据库链接

UniGene:

Hs.149342

SMR:

Q9GZX7

STRING:

9606.ENSP00000229335

KEGG:

hsa:57379

MIM: