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AIMP1 (基因名), Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (蛋白名), aimp1_human.

产品名称:

AIMP1 Antibody

货号:

P2214Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Multisynthase complex auxiliary component p43, EMAP2, SCYE1

序列号:

Q12904

反应性:

human

免疫原:

Recombinant human AIMP1 protein ( R2214h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human AIMP1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

EMAP-II in Human Prostate Cancer Tissue. EMAP-II was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using Mouse Anti-Human/Mouse/Rat EMAP-II Antibody at 5 μg/mL .

通用注释

亚单元:

Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus). Interacts with PSMA7.

功能:

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

亚细胞位置:

Nucleus Cytoplasm Cytosol Cytoplasmic vesicle Secretory vesicle Secreted Endoplasmic reticulum Golgi apparatus Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.

数据库链接

UniGene:

Hs.591680

SMR:

Q12904

STRING:

9606.ENSP00000378191

KEGG:

hsa:9255

MIM:

260600

Pfam: