首页 > 一抗 > ASPN Antibody

ASPN (基因名), Asporin (蛋白名), aspn_human.

产品名称:

ASPN Antibody

货号:

P1043Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Periodontal ligament-associated protein 1, PLAP-1, UNQ215/PRO241, PLAP1, SLRR1C

序列号:

Q9BXN1

反应性:

human

免疫原:

Recombinant human ASPN protein ( R1043h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Metabolism

规格 & 价格:

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Human ASPN Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Formalin-fixed and paraffin-embedded human hepatocarcinoma with ASPN Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. [antibody concentration 8 ug/ml]

通用注释

亚单元:

Interacts with TGFB1, TGFB2 and TGFB3. DCN, BGN, and FMOD inhibit binding to TGFB1. Interacts with BMP2. Interacts in vitro with type II collagen (By similarity). Interacts with type I collagen. DCN can inhibit collagen binding.

功能:

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

亚细胞位置:

Secreted Extracellular space Extracellular matrix

数据库链接

UniGene:

Hs.435655

SMR:

Q9BXN1

STRING:

9606.ENSP00000364694

KEGG:

hsa:54829

MIM: