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BBC3 (基因名), Bcl-2-binding component 3, isoforms 1/2 (蛋白名), bbc3_human.
产品名称:

BBC3 Antibody

货号:

P1909Rb-h

商标:
EIAab®
监管等级:
别名:

JFY-1, p53 up-regulated modulator of apoptosis, PUMA

序列号:
Q9BXH1
反应性:
human
免疫原:
Recombinant human BBC3 protein ( R1909h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
  • Human BBC3 Polyclonal Antibody
  • Human BBC3 Polyclonal Antibody
  • Human BBC3 Polyclonal Antibody
规格 & 价格: cart
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Human BBC3 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human BBC3 Polyclonal Antibody
Immunohistochemical analysis of paraffin-embedded human hepatoma, using BBC3 antibody at 1:500 dilution.
通用注释


亚单元:
Interacts with MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with BCL2 (PubMed:11463391). Interacts with BCL2L1/BCL-XL (PubMed:23340338). Interacts (via BH3 domain) with NOL3/ARC (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity).


功能:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).


亚细胞位置:
Mitochondrion Localized to the mitochondria in order to induce cytochrome c release.


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