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CANX (基因名), Calnexin (蛋白名), calx_human.

产品名称:

CANX Antibody

货号:

P0280Rb

商标:

EIAab^®

监管等级:

RUO

别名:

IP90, Major histocompatibility complex class I antigen-binding protein p88, p90

序列号:

P27824

反应性:

human,mouse

免疫原:

Recombinant human CANX protein ( R0280h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human CANX Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

CANX antibody detects CANX protein at cytosol on mouse testis by immunohistochemical analysis.

通用注释

亚单元:

Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (PubMed:22314232). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (PubMed:23826168). Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELENOK, STT3A, VCP AND SELENOS (PubMed:22016385). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (PubMed:21205830).

功能:

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

亚细胞位置:

Endoplasmic reticulum membrane Single-pass type I membrane protein Endoplasmic reticulum Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).

数据库链接

UniGene:

Hs.567968

STRING:

9606.ENSP00000247461

KEGG:

hsa:821

MIM:

114217

Pfam:

PF00262

Uniprot: