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DDR1 (基因名), Epithelial discoidin domain-containing receptor 1 (蛋白名), ddr1_human.
产品名称:

DDR1 Antibody

货号:

P15103Rb

商标:
EIAab®
监管等级:
别名:

CD167 antigen-like family member A, Tyrosine-protein kinase CAK, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, MCK-10, CD167a, Epithelial discoidin domain receptor 1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

序列号:
Q08345
反应性:
human,mouse,rat
免疫原:
corresponding to a sequence mapping at the Recombinant protein of Q08345
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human DDR1 Polyclonal Antibody
规格 & 价格: cart
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Human DDR1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry analysis in formalin-fixed, paraffin-embedded human breast carcinoma using a DDR1 polyclonal antibody
通用注释


亚单元:
Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.


功能:
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.


亚细胞位置:
Isoform 4 Cell membrane Single-pass type I membrane protein


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