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Ddr1 (基因名), Epithelial discoidin domain-containing receptor 1 (蛋白名), ddr1_mouse.
产品名称:

Mouse Ddr1/ Epithelial discoidin domain-containing receptor 1 Recombinant Protein
上皮细胞盘状结构域受体1

货号:

R15103m

商标:
EIAab®
监管等级:
别名:

CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, Protein-tyrosine kinase MPK-6, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, CD167a, Epithelial discoidin domain receptor 1, Cak, Eddr1, Mpk6

序列号:
Q03146
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Ddr1 Protein
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Mouse Ddr1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.


功能:
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.


亚细胞位置:
Cell membrane Single-pass type I membrane protein


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