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EZR (基因名), Ezrin (蛋白名), ezri_human.

产品名称:

EZR Antibody

货号:

P1297Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Cytovillin, Villin-2, p81, VIL2

序列号:

P15311

反应性:

human

免疫原:

corresponding to a sequence mapping at the 291-415aa of P15311

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human EZR Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

293T lysate was subjected to SDS-PAGE followed by Western Blot with EZR antibody at dilution of 1:300 (Observed molecular weight is about 70kDa)

通用注释

亚单元:

Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B (PubMed:9314537, PubMed:12651155, PubMed:15498789, PubMed:17616675, PubMed:17881735, PubMed:19555689). Interacts (when phosphorylated) with FES/FPS (PubMed:18046454). Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites (PubMed:12808036, PubMed:19111582). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX.

功能:

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

亚细胞位置:

Apical cell membrane Peripheral membrane protein Cytoplasmic side Cell projection Cell projection Microvillus membrane Peripheral membrane protein Cytoplasmic side Cell projection Ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cell cortex Cytoplasm Cytoskeleton Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).

数据库链接

UniGene:

Hs.487027

SMR:

P15311

STRING:

9606.ENSP00000338934

KEGG:

hsa:7430

MIM:

123900

Pfam: