首页 > 一抗 > WTAP Antibody

WTAP (基因名), Pre-mRNA-splicing regulator WTAP (蛋白名), fl2d_human.

产品名称:

WTAP Antibody

货号:

P1509Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Female-lethal(2)D homolog, WT1-associated protein, Wilms tumor 1-associating protein, hFL(2)D, KIAA0105

序列号:

Q15007

反应性:

human,mouse,rat

免疫原:

Recombinant human WTAP protein ( R1509h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human WTAP Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of human testis using WTAP polyclonal antibody at a dilution of 1:50.

通用注释

亚单元:

Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14 (PubMed:24407421, PubMed:24981863, PubMed:24316715). Interacts with WT1 (PubMed:11001926, PubMed:17095724). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

功能:

Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).

亚细胞位置:

Nucleus Nucleoplasm Nucleus speckle

数据库链接

UniGene:

Hs.446091

SMR:

Q15007

STRING:

9606.ENSP00000351141

KEGG:

hsa:9589

MIM: