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Wtap (基因名), Pre-mRNA-splicing regulator WTAP (蛋白名), fl2d_mouse.
产品名称:

Mouse Wtap/ Pre-mRNA-splicing regulator WTAP Recombinant Protein
Pre-mRNA-splicing调节器WTAP

货号:

R1509m

商标:
EIAab®
监管等级:
别名:

Female-lethal(2)D homolog, WT1-associated protein, Wilms tumor 1-associating protein

序列号:
Q9ER69
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Wtap Protein
规格 & 价格: cart
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Mouse Wtap Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14. Interacts with WT1. Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (By similarity). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145).


功能:
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.


亚细胞位置:
Nucleus Nucleoplasm Nucleus speckle


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