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HAT1 (基因名), Histone acetyltransferase type B catalytic subunit (蛋白名), hat1_human.

产品名称:

HAT1 Antibody

货号:

P15268Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Histone acetyltransferase 1, KAT1

序列号:

O14929

反应性:

human,mouse,rat

免疫原:

Recombinant human HAT1 protein ( R15268h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Development Biology

规格 & 价格:

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Human HAT1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of HAT1 in human lymph node shows strong nuclear positivity in germinal center cells.

通用注释

亚单元:

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.

功能:

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

亚细胞位置:

Isoform B Cytoplasm Nucleus Nucleus matrix Nucleus Nucleoplasm Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.

数据库链接

UniGene:

Hs.632532

SMR:

O14929

STRING:

9606.ENSP00000264108

KEGG:

hsa:8520

MIM:

603053

Pfam: