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EBI3 (基因名), Interleukin-27 subunit beta (蛋白名), il27b_human.

产品名称:

EBI3 Antibody

货号:

P9188Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, IL-27 subunit beta, IL27B

序列号:

Q14213

反应性:

human

免疫原:

Recombinant human EBI3 protein ( R9188h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human EBI3 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemistry-Paraffin: EBI3 Antibody - Human spleen tissue with EBI3 antibody at 1.5 ug/ml

通用注释

亚单元:

Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.

功能:

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.501452

STRING:

9606.ENSP00000221847

KEGG:

hsa:10148

MIM:

605816

Pfam: