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ILK (基因名), Integrin-linked protein kinase (蛋白名), ilk_human.

产品名称:

ILK Antibody

货号:

P1587Rb

商标:

EIAab^®

监管等级:

RUO

别名:

59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK, ILK1, ILK2

序列号:

Q13418

反应性:

human, mouse

免疫原:

Recombinant human ILK protein ( R1587h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human ILK Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ILK .

通用注释

亚单元:

Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts with LIMD2; leading to activate the protein kinase activity (PubMed:24590809).

功能:

Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

亚细胞位置:

Cell junction Focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Cell projection Lamellipodium Cytoplasm Myofibril Sarcomere

数据库链接

UniGene:

Hs.706355

SMR:

Q13418

STRING:

9606.ENSP00000299421

KEGG:

hsa:3611

MIM: