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PA2G4 (基因名), Proliferation-associated protein 2G4 (蛋白名), pa2g4_human.

产品名称:

PA2G4 Antibody

货号:

P1733Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Cell cycle protein p38-2G4 homolog, ErbB3-binding protein 1, hG4-1, EBP1

序列号:

Q9UQ80

反应性:

human,mouse,rat

免疫原:

Recombinant human PA2G4 protein ( R1733h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human PA2G4 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical analysis of formalin-fixed and paraffin-embedded human stomach cancer tissue using PA2G4 antibody(primary antibody dilution at 1:100).

通用注释

亚单元:

Isoform 2 interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Interacts with AKT1 (By similarity). Isoform 1 and isoform 2 interact with RNF20. Isoform 2 interacts with HUWE1. Interacts with DNAJC21 (PubMed:27346687).

功能:

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.

亚细胞位置:

Isoform 2 Cytoplasm

数据库链接

UniGene:

Hs.524498

SMR:

Q9UQ80

STRING:

9606.ENSP00000302886

KEGG:

hsa:5036

MIM: