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PDGFC (基因名), Platelet-derived growth factor C (蛋白名), pdgfc_human.

产品名称:

PDGFC Antibody

货号:

P0528Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Fallotein, Spinal cord-derived growth factor, VEGF-E, SCDGF, UNQ174/PRO200, PDGF-C, SCDGF

序列号:

Q9NRA1

反应性:

human, mouse

免疫原:

Recombinant human PDGFC protein ( R0528h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human PDGFC Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

PDGFC was detected in immersion fixed paraffin-embedded sections of human pancreatic cancer tissue using 1.0 μg/mL Anti- PDGFC Polyclonal Antibody.

通用注释

亚单元:

Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain).

功能:

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

亚细胞位置:

Cytoplasm Cytosol Secreted Nucleus Cytoplasmic granule Cell membrane Sumoylated form is predominant in the nucleus (PubMed:15247255). Stored in alpha granules in platelets (PubMed:15061151).

数据库链接

UniGene:

Hs.570855

SMR:

Q9NRA1

STRING:

9606.ENSP00000422464

KEGG:

hsa:56034

MIM:

608452

Pfam: