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PLA2R1 (基因名), Secretory phospholipase A2 receptor (蛋白名), pla2r_human.

产品名称:

PLA2R1 Antibody

货号:

P2020Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, M-type receptor, PLA2-R, CLEC13C

序列号:

Q13018

反应性:

human

免疫原:

corresponding to a sequence mapping at the 188-400aa of Q13018

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human PLA2R1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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数据
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常见问题解答
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R&D 技术数据

Immunohistochemical staining of human kidney using PLA2R1 antibody.

通用注释

亚单元:

N/A

功能:

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

亚细胞位置:

Isoform 2 Secreted

数据库链接

UniGene:

Hs.410477

SMR:

Q13018

STRING:

9606.ENSP00000283243

KEGG:

hsa:22925

MIM:

604939

Pfam:

PF00040

Uniprot:

Q13018

相关产品

Mouse Pla2r1 ELISA Kit

Bovine PLA2R1 ELISA Kit

Mouse Pla2r1 CLIA Kit

Bovine PLA2R1 CLIA Kit

Mouse Pla2r1 Protein

序列长度:

1463

序列:

仅供参考，详细请咨询（services@eiaab.com）

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ENILISDLEK | SDQ

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该产品尚未在任何出版物中被引用。

[1].

多克隆抗体PLA2R1可以申请产品的免费试用装吗？

我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同，我们将提供换货或退款服务。如果抗体用于未测试的物种或应用，我们不提供换货或退款服务。EIAab产品的投诉期为6个月，逾期不予受理。

[2].

多克隆抗体PLA2R1说明书上的信息是及时更新的吗？

说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时，说明书会实时更新，因此说明书绝不会过时。

[3].

如何选择合适的一抗？

请先确定您要检测的种属和使用的实验方法，然后查找相关产品，根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测，则您可以放心地购买该产品。

[4].

多克隆抗体PLA2R1在其他物种或应用中测试过吗？

所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后，就会立即更新物种和应用。

[5].

如何保存多克隆抗体PLA2R1？

我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存，我们不能保证抗体的性能。

[6].

如何分装多克隆抗体PLA2R1？

请根据一次实验的常用量进行分装。每等份不应少于10μl；每等份的量越少，抗体储液浓度受蒸发和管壁吸附的影响越大。

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