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SLC6A4 (基因名), Sodium-dependent serotonin transporter (蛋白名), sc6a4_human.

产品名称:

SLC6A4 Antibody

货号:

P2290Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

5HT transporter, Solute carrier family 6 member 4, 5HTT, SERT, HTT, SERT

序列号:

P31645

反应性:

human

免疫原:

Recombinant human SLC6A4 protein ( R2290h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human SLC6A4 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of formalin-fixed and paraffin embedded rat spleen tissueusing SLC6A4 antibody.

通用注释

亚单元:

Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.

功能:

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

亚细胞位置:

Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069).

数据库链接

UniGene:

Hs.134662

SMR:

P31645

STRING:

9606.ENSP00000261707

KEGG:

hsa:6532

MIM:

103780

Pfam: