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SIRT5 (基因名), NAD-dependent protein deacylase sirtuin-5, mitochondrial (蛋白名), sir5_human.

产品名称:

SIRT5 Antibody

货号:

P11384Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Regulatory protein SIR2 homolog 5, SIR2-like protein 5, SIR2L5

序列号:

Q9NXA8

反应性:

human,mouse,rat

免疫原:

Recombinant human SIRT5 protein ( R11384h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human SIRT5 Polyclonal Antibody

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产品说明书

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通用注释

亚单元:

Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.

功能:

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

亚细胞位置:

Isoform 2 Mitochondrion

数据库链接

UniGene:

Hs.567431

SMR:

Q9NXA8

STRING:

9606.ENSP00000368552

KEGG:

hsa:23408

MIM: